stress is recognized to be involved in the pathogenesis of lifestyle-related
illnesses, including malignancies, atherosclerosis, hypertension, diabetes
mellitus, ischemic diseases, and environmental poisoning . Oxidative stress has
been defined as harmful because oxygen free radicals strike biological
molecules such as lipids, proteins, and DNA molecule. However, oxidative stress
also has a useful role in physiologic adjustment and in the regulation of
intracellular signal transduction1.
a more useful definition of oxidative stress may be “a state where oxidative
forces exceed the antioxidant systems due to loss of the balance between them.”
The biomarkers that can be used to assess oxidative stress in vivo have been
attracting because the accurate measurement of such stress is necessary for
investigation of its role in lifestyle diseases as well as to evaluate the
efficacy of treatment1.
showed that biomarker 8-hydroxy-2-deoxyguanosine (8-OHdG) or
has been a crucial marker for measuring the effect of endogenous
oxidative damage to DNA and as a factor of initiation and promotion of
carcinogenesis process. In recent years, 8-OHdG has been used widely in many
studies not only as a biomarker for the measurement of endogenous oxidative DNA
damage but also as a risk factor for many diseases including cancer2.
a clinical point of view, if biomarkers that reveal the extent of oxidative
stress were available, such markers would be useful for
physicians to achieve an insight into the pathological features of various
diseases and assess the efficacy of drugs.
contrast to numerous studies on the role of oxidative stress including
atherosclerosis, hypertension, diabetes mellitus, ischemic diseases, and
malignancies, Limited studies have been done on the role of oxidative stress in
determining the severity of acute and fatal poisoning as well as the therapies.
seems that the determination of oxidative stress in the diagnosis of severity
and response to therapy of acute poisoning can open up a new horizon.