also appear to modulate the activity of the direct and indirect pathways via
effects on dopamine receptors. In cultured striatal neurons, treatment with
several effects: it blocked cellular response to D2 binding, but approximately
D1 binding on enzymatic activity in neurons (Maus et al., 1989) and decreased
calcium channels in striatal MSN’s (Mermelstein, Becker, & Surmeier, 1996).
when estradiol benzoate was injected into both OVX and CAST rats, there was a
(30-minutes following injection) decrease in dopamine binding at D2 receptors
in OVX rats (Bazzett & Becker, 1994). Additionally, both acute (Levesque
subchronic (Tonnaer et al., 1989) administration of estradiol in OVX rats
of high to low affinity striatal D2 receptors. In contrast, OVX leads to
decreases in D1
density compared to intact females (Levesque, Gagnon, & DiPaolo, 1989).
suggest that the presence of estradiol in striatal motor pathways (in female
enhance the functioning of the direct pathway, either by enhancing D1 activity,
the direct pathway by blocking D2 binding or limiting GABA-ergic inputs from